Neural Mechanisms of LEARNING

Christine Grienberger, Ph.D.

Department of Biology

Brandeis University

The Grienberger lab will open July 2021!

We are recruiting on all levels!!

The brain’s ability to learn is critical for executing tasks that ensure an individual's survival. We combine experimental work and computational methods to understand the synaptic, cellular, and circuit-level computations that allow the brain to produce these complex adaptive behaviors. Our focus is the entorhinal-hippocampal circuit and its downstream projection targets, a network of brain areas known to be essential for spatial learning.

We use various techniques, including two-photon Ca2+ imaging, whole-cell patch-clamp recordings, and optogenetic perturbation of neuronal activity, to investigate the single-cell and population activity in various brain regions of mice actively engaged in a spatial memory task. This work will open new pathways to investigate the fundamental principles underlying learning in the intact and diseased brain.

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